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IPSS Score

Bone Marrow Blasts (%)
Karyotype
Cytopenias

Cytopenias: Neutrophils < 1.5 x 109/L, Platelets < 100 x 109/L, Hemoglobin < 10 g/L ( 6.2 mM).

 All patients (n=816):

Risk group

Score

Median survival

(years)

Time to AML transformation

(for 25% in years)

Low risk

0

5.7

9.4

INT-1

0.5-1.0

3.5

3.3

INT-2

1.5-2.0

1.2

1.1

High risk

≥2.5

0.4

0.2

 

Patients below age 60 (n=205):

Risk group

Score

Median survival

(years)

Time to AML transformation

(for 25% in years)

Low risk

0

11.8

>9.4

INT-1

0.5-1.0

5.2

6.9

INT-2

1.5-2.0

1.8

0.7

High risk

≥2.5

0.3

0.2 

Reference: Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997; 89: 2079-2088.