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default Male sex and the pattern of recurrent myeloid mutations are strong independent predictors of blood transfusion intensity in patients with myelodysplastic syndromes. (265 downloads)
default TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups. (262 downloads)
default A three-dimensional in vitro model of erythropoiesis recapitulates erythroid failure in myelodysplastic syndromes. (270 downloads)
default Nordic Guidelines for Germline Predisposition to Myeloid Neoplasms in Adults: Recommendations for Genetic Diagnosis, Clinical Management and Follow-up. (244 downloads)
default Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes. (254 downloads)
default Myelodysplastic syndromes: moving towards personalized management. (251 downloads)
default Prognostic scoring systems and comorbidities in chronic myelomonocytic leukaemia: a nationwide population-based study. (256 downloads)
default SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS. (262 downloads)
default Clonal hematopoiesis in elderly twins: concordance, discordance and survival. (271 downloads)
default Improved Outcomes after Allogenic Hematopoietic Stem Cell Transplantation with Fludarabine/Treosulfan for Patients with Myelodysplastic Syndromes. (252 downloads)
default Clonal hematopoiesis evolves from pre-treatment clones and stabilizes after end of chemotherapy in patients with MCL (254 downloads)
default Activation of a Subset of Evolutionarily Young Transposable Elements and Innate Immunity are Linked to Clinical Responses to 5-Azacytidine. (256 downloads)
default Clinical impact of clonal hematopoiesis in patients with lymphoma undergoing ASCT: A national population-based cohort study (257 downloads)
default Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations (899 downloads)
default Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells. (808 downloads)
default Prognostic scoring systems for myelodysplastic syndromes (MDS) in a population-based setting: a report from the Swedish MDS register. (910 downloads)
default Sipa1 deficiency-induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm. (756 downloads)
default Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: a European LeukemiaNet study. (740 downloads)
default Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML. (772 downloads)
default Prognostic impact of a suboptimal number of analyzed metaphases in normal karyotype lower-risk MDS. (782 downloads)
default Megakaryocytes harbour the del(5q) abnormality despite complete clinical and cytogenetic remission induced by lenalidomide treatment. (754 downloads)
default Labile plasma iron levels predict survival in patients with lower-risk myelodysplastic syndromes. (769 downloads)
default Gene expression and risk of leukemic transformation in myelodysplasia. (760 downloads)
default Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes. (783 downloads)
default Clinical characteristics and outcomes according to age in lenalidomide-treated patients with RBC transfusion-dependent lower-risk MDS and del(5q). (793 downloads)
default Ex Vivo expanded adaptive NK cells effectively kill primary acute lymphoblastic leukemia cells (1095 downloads) Popular
default SF3B1-initiating Mutations in MDS with ring sideroblasts target lymphomyeloid hematopoietic stem cells (972 downloads)
default The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes (1037 downloads) Popular
default Cytomorphology review of 100 newly diagnosed lower-risk MDS patients in the European LeukemiaNet MDS (EUMDS) registry reveals a high inter-observer concordance (944 downloads)
default Comprehensive mapping of the effects of azacitidine on DNA methylation, repressive/permissive histone marks and gene expression in primary cells from patients with MDS and MDS-related disease (1009 downloads) Popular
default The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes (1027 downloads) Popular
default Allogeneic hematopoietic stem cell transplantation for MDS and CMML: recommendations from an international expert panel (1173 downloads) Popular
default Erythropoiesis-stimulating agents significantly delay the onset of a regular transfusion need in nontransfused patients with lower-risk myelodysplastic syndrome (963 downloads)
default Progression in patients with low- and intermediate-1-risk del(5q) myelodysplastic syndromes is predicted by a limited subset of mutations (1015 downloads) Popular
default Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice (1039 downloads) Popular
default Evaluating variant calling tools for non-matched next-generation sequencing data (1012 downloads) Popular
default Cancer-specific changes in DNA methylation reveal aberrant silencing and activation of enhancers in leukemia (1137 downloads) Popular
default Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality (1068 downloads) Popular
default GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndrome (1236 downloads) Popular
default Impact of socioeconomic status on disease phenotype, genomic landscape and outcomes in myelodysplastic syndromes (906 downloads)
default Mutations in histone modulators are associated with prolonged survival during azacitidine therapy (1394 downloads) Popular
default The European Hematology Association Roadmap for European Hematology Research: a consensus document (1058 downloads) Popular
default Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF3B1 mutated refractory anaemia with ring sideroblasts (1274 downloads) Popular
default Imprint of 5-azacytidine on the natural killer cell repertoire during systemic treatment for high-risk myelodysplastic syndrome (1072 downloads) Popular
default Validation of the revised international prognostic scoring system (IPSS-R) in patients with lower-risk myelodysplastic syndromes: a report from the prospective European LeukaemiaNet MDS (EUMDS) registry (1199 downloads) Popular
default SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts (1463 downloads) Popular
default Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells (759 downloads)
default High-throughput mutational screening adds clinically important information in myelodysplastic syndromes and secondary or therapy-related acute myeloid leukemia (1216 downloads) Popular
default Self-perception of symptoms of anemia and fatigue before and after blood transfusions in patients with myelodysplastic syndromes (1304 downloads) Popular
default Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes (787 downloads)
default Specific scoring systems to predict survival of patients with high-risk myelodysplastic syndrome (MDS) and de novo acute myeloid leukemia (AML) after intensive antileukemic treatment based on results of the EORTC-GIMEMA AML-10 and intergroup CRIANT studie (1076 downloads) Popular
default Minimal morphological criteria for defining bone marrow dysplasia: a basis for clinical implementation of WHO classification of myelodysplastic syndromes (775 downloads)
default Outcomes in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with isolated deletion 5q treated with lenalidomide: a subset analysis from the MDS-004 study (1207 downloads) Popular
default Driver somatic mutations identify distinct disease entities within myeloid neoplasms with myelodysplasia (910 downloads)
default Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes (781 downloads)
default A mutation in the H/ACA box of telomerase RNA component gene (TERC) in a young patient with myelodysplastic syndrome (1387 downloads) Popular
default Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo (776 downloads)
default A pilot phase I dose finding safety study of the thrombopoietin-receptor agonist, eltrombopag, in patients with myelodysplastic syndrome treated with azacitidine (1192 downloads) Popular
default A mutation in the H/ACA box of telomerase RNA component gene (TERC) in a young patient with myelodysplastic syndrome (870 downloads)
default p53 protein expression independently predicts outcome in patients with lower-risk myelodysplastic syndromes with del(5q) (890 downloads)
default Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo (1413 downloads) Popular
pdf Limited clinical efficacy of azacitidine in transfusion-dependent, growth factor-resistant, low- and Int-1-risk MDS: Results from the nordic NMDSG08A phase II trial (1296 downloads) Popular
default Azacitidine induces profound genome-wide hypomethylation in primary myelodysplastic bone marrow cultures but may also reduce histone acetylation (1160 downloads) Popular
default Cardiac iron overload assessed by T2* magnetic resonance imaging and cardiac function in regularly transfused myelodysplastic syndrome patients (1184 downloads) Popular
default Challenges of phase III trial design for novel treatments in diseases with no standard treatment: the AZA-001 myelodysplasia study model (804 downloads)
default Clinical and biological implications of driver mutations in myelodysplastic syndromes (1389 downloads) Popular
default Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet (844 downloads)
default Identification of gene expression-based prognostic markers in the hematopoietic stem cells of patients with myelodysplastic syndromes (1140 downloads) Popular
default Role of reduced-intensity conditioning allogeneic hematopoietic stem-cell transplantation in older patients with de novo myelodysplastic syndromes: an international collaborative decision analysis (738 downloads)
default A multivariate analysis of the relationship between response and survival among patients with higher-risk myelodysplastic syndromes treated within azacitidine or conventional care regimens in the randomized AZA-001 trial (693 downloads)
default Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions (813 downloads)
default The transporter ABCB7 is a mediator of the phenotype of acquired refractory anemia with ring sideroblasts (728 downloads)
default Lenalidomide does not increase AML progression risk in RBC transfusion-dependent patients with Low- or Intermediate-1-risk MDS with del(5q): a comparative analysis (769 downloads)
default Inappropriately low hepcidin levels in patients with myelodysplastic syndrome carrying a somatic mutation of SF3B1 (746 downloads)
default Rationale for the clinical application of flow cytometry in patients with myelodysplastic syndromes: position paper of an International Consortium and the European LeukemiaNet Working Group (635 downloads)
default Bone marrow dendritic cells are reduced in patients with high-risk myelodysplastic syndromes (959 downloads)
default Downregulation but lack of promoter hypermethylation or somatic mutations of the potential tumor suppressor CXXC5 in MDS and AML with deletion 5q (831 downloads)
pdf Evaluation of Azacitidine in transfusion-dependent, Epo-refractory patients with lower-risk MDS ( pdf, 83 KB ) (1495 downloads) Popular
default Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML (829 downloads)
default Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms (808 downloads)
default Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks (769 downloads)
default Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts (728 downloads)
default Marked down-regulation of nucleophosmin-1 is associated with advanced del(5q) myelodysplastic syndrome (722 downloads)
default Continued azacitidine therapy beyond time of first response improves quality of response in patients with higher-risk myelodysplastic syndromes (677 downloads)
default TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression (745 downloads)
pdf Clinical effect of increasing doses of lenalidomide in high-risk myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities (1075 downloads) Popular
default Effects of azacitidine compared with conventional care regimens in elderly (≥ 75 years) patients with higher-risk myelodysplastic syndromes (716 downloads)
pdf Significance of JAK2 and TET2 mutations in myelodysplastic syndromes (1207 downloads) Popular
default Persistent malignant stem cells in del(5q) myelodysplasia in remission (807 downloads)
default Management and supportive care measures for adverse events in patients with myelodysplastic syndromes treated with azacitidine (835 downloads)
pdf Maintenance treatment with azacytidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia following MDS in complete remission after induction chemotherapy (1048 downloads) Popular
default Prolonged survival with improved tolerability in higher-risk myelodysplastic syndromes: azacitidine compared with low dose ara-C (739 downloads)
default Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia (751 downloads)
default Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression (684 downloads)
pdf Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study (1126 downloads) Popular
pdf Erythropoietin and G-CSF treatment associated with improved survival in myelodysplastic syndrome (1165 downloads) Popular
pdf Supportive care, growth factors, and new therapies in myelodysplastic syndromes (1142 downloads) Popular
default Azacitidine prolongs overall survival and reduces infections and hospitalizations in patients with WHO-defined acute myeloid leukaemia compared with conventional care regimens: an update (697 downloads)
default The effects of continued azacitidine treatment cycles on response in higher risk patients with myelodysplastic syndromes: an update (688 downloads)
pdf Negative Effect of DNA Hypermethylation on the Outcome of Intensive Chemotherapy in Older Patients with High-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia following Myelodysplastic Syndrome (980 downloads)

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